Author's Name:	Sonu Khanka & Dharmendra Kumar
Subject Area:	Health Science
Subject	Other
Section	Research Paper

CdCl2, Vitamin E, Vitamin C, AST, ALT and ALP

Cadmium is a well-known human carcinogen and a potent hepatotoxin induce severe liver damage by altering several marker enzymes. Vitamin E and Vitamin C are effective antioxidants and free radical scavenger against metal toxicity. Therefore, present study has been design to investigate the potential protective effect of vitamin E and vitamin C separately and in combined form against hepatotoxicity induced by cadmium chloride in laboratory chicks. Investigation was carried out by monitoring the AST, ALT and ALP level in liver. The level of AST, ALT and ALP increased significantly (p<0.005) in cadmium treated chicks as compared to control group, vitamin E and vitamin C treated groups. Present results reveals that intoxication of cadmium chloride (CdCl2) induce hepatotoxicity and disturb the liver functions. When cadmium chloride treated chicks administered with vitamin E and vitamin C separately, the level of protection reach up to control level. On other hand, co- administration of both vitamins (Vit E + Vit. C) in combined form lead to the most significant protection against cadmium toxicity in comparison to vitamin E and vitamin C separately. In conclusion, results demonstrated that intoxication of cadmium chloride (CdCl2) induce hepatotoxicity and co-administration of antioxidant i.e. vitamin E and vitamin C separately or in combined form leads to significant decrease in AST, ALT and ALP values in liver and exhibit improvement in liver functions. However, combined form of both vitamins was observed most protective.