HEMATOBIOCHEMICAL CHANGES OF LEAD POISONING AND ITSIMPROVEMENT WITH CORIANDER(CORIANDRUM SATIVUM) EXTRACTS IN RABBITS.

Author's Name: Gehad Rashad Donia
Subject Area: Health Science
Subject Veterinary Science
Section Research Paper

Keyword:

Hematobiochemical, heart, lung, Lead, Coriandrum sativum, Rabbits


Abstract

Rabbit is considered a very suitable animal model for lead intoxication with regard to haem synthesis, Coriandrum sativum is widely distributed and mainly cultivated for the seeds consequently, the current study planned to screen the protective effect of coriander aqueous and ethanolic seeds extracts on lead-induced body weight, hematobiochemical and heart & lung histopathological alternations in male rabbits. For this purpose, a daily dose of lead acetate(40 mg/kg body weight by oral gavage) for seven days was given to animals, however from day eight they received an oral dose of coriander extracts (300 and 600 mg kg-1 b.w. aqueous extract and 250 and 500 mg kg-1 b.w. ethanolic extract) along with lead acetate (Pb (CH3COO)2) daily for 33 days. The results showed that, weights of intoxicated rabbits has protected by coriander supplementation as compared to lead exposed animals. RBC count, WBC count, Hb level and serum Tp, Alb and Glb contents were significantly decreased in the lead treated animals while, total bilirubin levels were significantly increased after implication of lead metal. However, marked improvement in both hematological and serum biochemical changes was observed in lead treated rabbits which had oral administration of coriander extracts especially in high doses. Also the correlation between different parameters was shown. An extension of that, lead caused histopathological changes in heart and lung of male rabbites while coriander extracts administration to lead treated animals resulted in overall improvement in these organs damage, emphasizing its strong antioxidant properties. Oral administration of coriander extracts to lead acetate treated groups decline the deranged parameters to some extent. Results revealed that, treatment with coriander extracts significantly protect against lead induced toxicity and warrant the isolation and identification of the active compounds responsible for its antioxidant effect.

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