| Author's Name: |
Paojatong Singson & Meenakshi Bawari |
| Subject Area: |
Life Sciences |
| Subject |
Other |
| Section |
Research Paper |
Keyword:
VitaminE, Plumbago zeylanica, Neurotoxicity, LPO, GOT, GPT, neuroprotection.
Abstract
Plumbago zeylanica is a medicinal plant with various therapeutic application since time immemorial, in the present study adverse brain toxicity of this vital medicinal plant was evaluated in biochemical parameters. The significant pathological changed in histological study were also noted in Plumbago zeylanica plant extract treated mice brain. alteration in biochemical parameters was noted with significant alteration level of LPO and GOT, GPT activity which may be due to plant extract admistration. The elevation in cerebral cortex was significant (p<.01) in Plumbago zeylanica treaeted mice and mid brain tissue of Plumbago zeylanica also showed significant(p<.05) elevation in all the biochemical parameters in plant extract treated group. In the present study Pretreatment of antioxidant vit.E with plant extract group showed recovery from stress when compared to plant extract treated alone. The cerebral cortex and mid brain tissue of pretreatment with Vit.E group showed highly significant in the present study.