Author's Name:	Dr. PRABHAKAR S. JIRVANKAR & Dr. MAYUR SANJAY NANDWALKAR
Subject Area:	Health Science
Subject	Medicine and Dentistry
Section	Research Paper

Dengue, DHF, Thrombocytopenia, NS1

Dengue fever, an acute febrile arbo-viral disease has become a major public health problem in tropical and subtropical regions of the world especially in India, due to the morbidity and mortality it causes.57 There has been a considerable increase in the geographic spread, number of cases and severity of the disease in the past four decades. Dengue infection has been known to be endemic in many parts of India for over two centuries and outbreaks have been reported at regular intervals from almost all parts of India.18 The present study was done at Tertiary care hospital in Maharashtra .The study population comprised of 120 adult Dengue fever cases which were positive for either NS 1 or IgM ELISA or for both . Cases were selected according to inclusion criteria. Each patient underwent detailed Clinical, Serological and Biochemical examination .Out of the total study population majority of the cases occurred in Monsoon and Post Monsoon period as there is increase in number of vector for the disease, 70% cases were of age between 13 to 30 years, Fever was the most common presenting symptom, Thrombocytopenia was seen in 76.27% Male and 49.18% Female patients which was significantly higher in Males. Hepatomegaly and Tachypnoea were seen in 10% of cases.Out of the total 120 cases 34.16% cases had Dengue fever disease with warning signs and 9.16% cases had severe Dengue disease .Total 95% cases had recovered from Dengue fever and discharged. Hemorrhagic manifestations were seen most significantly when platelet count was less than 20000 per cmm. Deranged liver enzymes was found in 30% of cases. 7.5% cases had pneumonitis, 4.16% cases had multiorgan dysfunction syndrome and 4.16% cases died.