THERMO-CHEMORADIATION INDUCED MR DIFFUSION CHANGES AFTER BRAIN GLIOMA TREATMENT

Author's Name: Leila Khalafi, Seied Rabi Mehdi Mahdavi and Farshid Arbabi
Subject Area: Health Science
Subject Medicine and Dentistry
Section Research Paper

Keyword:

Hyperthermia, Glioblastoma multiform, Radiotherapy, Apparent Diffusion Coefficient, Chemotherapy, Thermal enhancement factor, Celsius, Diffusion weighted imaging


Abstract

Background: Glioblastoma multiform (GBM) is a common brain-tumour. We expanded hyperthermia (HT) experiments over the changes of the apparent diffusion coefficient (ADC) in MR imaging to assess thermal beneficial effect in combination to chemo-radiation therapy. Patients and methods: There were 34 GBM patients in two equal groups of chemo-radiation therapy (RT) and chemo radiation therapy plus HT (RHT), and each group age ranging from 26 to 76 years. HT was done in 10 sessions for RHT group after initial calibration. ADC values thermal enhancement factor were calculated after treatments for both tumour and normal brain tissues. Result: There was a significant difference of ADC values between before and after treatments in tumour region of RHT group (P =0.002) and it wasn’t significant in normal part of the brain tissue and TEF based on ADC values was 1.33. Conclusion: This preliminary study shows promising result with hyperthermia in term of ADC changes.

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